![]() ![]() To illustrate this point, 20 different random allocation sequences were generated for two treatments that had a total sample size of 20 patients. Procedures to avoid completely include using hospital chart numbers, alternating patients sequentially or assigning by date of birth.īecause simple random allocation has no relationship with prior assignment, unequal group sizes can happen by chance, especially in small sample sizes. Therefore, they are not generally recommended. However, these manual methods in practice often become nonrandom, are difficult to implement and do not leave an audit trail. There are manual methods of achieving random allocation such as tossing a coin, drawing lots or throwing dice. Good methods of generating a random allocation sequence include using a random-numbers table or a computer software program that generates the random sequence. In simple random allocation, treatment assignment is made by chance without regard to prior allocation (that is, it bears no relation to past allocations and it is not discoverable ahead of time). Simple random allocation is the easiest and most basic approach that provides unpredictability of treatment assignment. What are acceptable ways of generating a random sequence? ![]()
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